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Cars as a metaphor for understanding obesity

If we want to understand the accumulation of excess body fat, it's tempting to focus our attention on the location that defines the condition: adipose tissue.  Ultimately, the key question we want to answer is the following: why does fat enter adipose tissue faster than it exits?

It follows that if we want to understand why obesity occurs, we should seek to understand the dynamics of fat trafficking in adipose tissue, and the factors that influence it.  Right?

I don't think this is right, and here's a metaphor that explains why.

The speed of a car depends primarily on the force that its wheels exert on the asphalt below them.  If we want to understand why cars move quickly sometimes, and slowly at other times, we should seek to understand the dynamics of how force is transferred from the wheels to the asphalt, and the factors that influence it, right?

As you may have already surmised, that wouldn't be a very effective way of understanding car speed. To understand car speed, we have to move up the causal chain until we get to the system that actually regulates speed-- the person in the driver's seat.  Looking at the problem from the perspective of the wheels is not an effective way of understanding the person in the driver's seat.  Once we understand the driver, then we also understand why the wheels move how they do.

Similarly, in obesity, we have to move up the causal chain until we find the system that actually regulates body fatness.  The only known system in the human body that regulates body fatness is the brain.  Once we understand how the brain regulates body fatness, we'll understand why fat enters adipose tissue faster than it exits sometimes, eventually leading to obesity.

We already know a lot about how this process works, and that's why I focus my attention on the brain and behavior rather than the biochemical mechanics of adipose tissue.

Keep Left Jeremy Corbyn, It's the Key to Your Success

My latest column for Sputnik:

For a man who we're repeatedly told is "unelectable," Jeremy Corbyn seems pretty good at winning elections. He's been an MP since 1983, winning his seat eight times at a general election - and in 2015, he increased his vote in Islington North by 5.8%.

Against all the odds — and all the predictions of the "punditocracy," he was elected Labour leader last summer and increased his vote percentage again when challenged for the leadership this summer. That achievement was all the more impressive when you consider the large number of Corbyn supporting members who were prevented from voting in the poll by Labour's NEC and the party's Compliance Unit.

You can read the whole article here


Robert Hartford-Davis, 1968
Starring: Peter Cushing, Sue Lloyd, Kate O’Mara, Noel Trevarthen

A renowned plastic surgeon, Sir John Rowan (Peter Cushing), is at a party with his young girlfriend Lynn (Sue Lloyd), a model, when things get out of hand. He wants to leave, but she’s being fawned over by a photographer, and a scuffle breaks out in the crowd; a photo light falls over, smashing right on Lynn’s face, ruining it. It becomes Rowan’s obsession to make a surgical breakthrough and repair her beauty, and he begins experimenting with a series of (I believe) hypothalamus transplants, which at first seems like a miraculous cure and her face is restored without any hint of scarring or trauma. But this is only temporary and soon Rowan must replace the transplant, causing him to find increasingly homicidal ways to procure new glands…

Anyone who reads this blog is well aware of my frenzied love for Peter Cushing (two words: slap fetish), but I have to admit that while I really enjoy Corruption, I don’t quite rank it alongside some of his other performances from the late ‘60s through early ‘70s, though the bar is set quite high with things like the Sherlock Holmes (1968) TV series, Twins of Evil (1971), Dracula A.D. 1972 (1972), Fear in the Night (1972), and — drumroll — Horror Express (1972). In a weird way, I think the fact that Corruption was unavailable for so long has inflated its reputation, a bit, as a truly nasty piece of work. Cushing is nowhere near as maniacal as he is in Twins of Evil or Fear in the Night, or even Madhouse (1974), and the film’s interesting twist (this isn’t really a spoiler) is that he is goaded into killing by Lynn, who is almost maniacally obsessed with becoming beautiful — and staying that way. Though they have some traits in common, Sir John Rowan is a far cry from the Baron Frankenstein.

It’s also strange to think how neglected director Robert Hartford-Davis has been compared to other British genre directors; no disrespect to Terence Fisher or Pete Walker, but there are other talents out there. Hartford-Davis directed some other horror films, such as The Black Torment (1964), Incense for the Damned (1970), and The Fiend (1972), all of which I’ll be reviewing for my British horror series. If I had to sum up these titles (including Corruption), I think the best way I could describe them is flawed, but always interesting, and as far as low budget genre cinema goes, there’s not a lot more than I could ask for. I’m hoping some of his other titles get more attention and wider releases in the future. Unlike some of the other British genre directors, who as a rule tended to stick to similar themes, Hartford-Davis is at least in part interesting because he was all over the place. Corruption is essentially a riff on the glorious Eyes Without a Face (1960), but is a thoroughly British grindhouse interpretation of the material (though admittedly it doesn’t approach the level of insanity found in Jess Franco’s The Awful Dr. Orloff or Michael fucking Pataki’s Mansion of the Doomed…).

One of the best — and also most awkward — things about the film is that everything is set in swinging London. This results in a lot of unintentional, often unpleasant humor, and it has everything from a ridiculous party to an Austin Powers-like photo shoot that must be seen to be believed. Swinging London is admittedly one of my favorite time period settings for late ‘60s/early ‘70s horror and I hope that one day I can do a swinging London film festival, complete with things like Psychomania, Deadly Sweet, Dracula A.D. 1972, Raw Meat, and Scream and Scream Again. (Appropriate costumes will be mandatory.) Speaking of costumes, Cushing’s Sir Rowan is endearingly out of place in his fiancee’s world and, like so much British cinema from this period, much of the tension — and his encroaching, increasingly sweaty and disheveled madness — comes from this divide between free-wheeling youth and the reserved, traditional older generation.

I think part of why this film was soured a bit for me — and where some of the aforementioned youth comes into play — is the twist ending, although it’s not quite a surprise twist, but more a directional change of course, a sharp left turn that basically transforms this into a home invasion film (and with very, very few exceptions, I hate those). Rowan and Lynn go off to an isolated seaside cottage and hope to ensnare a lonely young woman, but she isn’t all that she seems. And so on. Despite that, this is a solid effort from Hartford-Davis and Cushing, who both seem to be having a great time, though I believe Cushing later said it was one of his worst films. Hammer-regular Kate O’Mara (The Vampire Lovers, The Horror of Frankenstein) is sadly underused, but keep your eyes peeled for other genre actresses like Vanessa Howard (Girly) and Valerie Van Ost (The Satanic Rites of Dracula).

Even though it’s not among my favorite Cushing films, or even British horror movies, Corruption is one of those sleaze gems that soundly fits under the description of “grindhouse” — so of course it’s fitting that it was restored and released on Blu-ray by the great Grindhouse Releasing with two versions of the film (the US/UK version and the gorier and more explicit European cut) and a load of special features. They go above and beyond with all of their releases — and all of the titles they chosen really have something special — but this was an obvious labor of love and both the release and the film come recommended. And let us not forget the amazing tagline: “CORRUPTION Is Not A Woman's Picture! Therefore: No Woman Will Be Admitted Alone To See This Super-Shock Film!” Perhaps the real problem is not with Corruption, but that I’m a woman and I watched the film alone.

Episode Delayed till Next Week

Hello to all followers of the History of Islam podcast! Unfortunately this week's episode will have to be delayed until next week due to issues in the production process. Hopefully this won't happen again, I could have forced out an episode but it would have been incredibly rushed and the quality would be almost certainly sub-par. Essentially it is an issue of quantity vs quality and I hope you all are in support of my decision to favour quality over quantity. What I definitely do not want to do is to just publish an episode for the sake of doing so, my ultimate goal is for every second of every episode to be valuable to the listener whether it be as an informative or entertaining device. Please bear with me in these coming weeks, I promise that we will eventually return to a smoother, more reliable schedule.

That is all from me for now, I will see you next Monday which is the 3rd of October till then take care of yourselves!







可以的話盡量全家一起完整的走完Roll Turtle所參加的活動。





原作者:Paul Hlebowitsh 於 09/19/16 09:51:00 am




  大概講一下背景:我是2016全美解謎冠軍賽(2016 US Puzzle Championship)前十強。我持續設計謎題大約有十年了,而《RYB》是我的第一款遊戲。














  1. 將中央那塊切成幾個小的多邊形,如此就有更多塊多邊形來對外面的東西下條件。

  1. 加入幾塊能夠提供更多條件給外側三角形的多邊形。

















  如果您喜歡這篇文章,煩請考慮支持一下Steam Greenlight上的《RYB》,或追蹤我的@FLEBpuzzles,裡頭有更多的謎題內容喔。


Edward Snowden: The hypocrisy is in the (Washington) Post

My latest article- for OpEdge

Consider the following: A newspaper receives documents about mass state surveillance from a whistleblower. It publishes a selection of the material. It is awarded a Pulitzer Prize for its reporting of the leaks.
Then, a couple of years later, having made money from the whistleblower and gained a prestigious award - it publishes an editorial arguing that the whistleblower- who had to leave his country, his family and loved ones and claim political asylum in another - does not deserve an official pardon.
Whatever your views are on whistleblowers, I’m sure you’ll agree that the newspaper has behaved pretty reprehensibly. We can talk about hypocrisy, betrayal, double standards, treachery - and also think of quite a few unprintable words to describe what the paper has done.
But really, the behavior of the Washington Post - the newspaper in question - should not surprise us.

You can read the whole piece here.

Sabia que a casca da fruta...

A casca da fruta e a pele dos frutos gordos (ex: amêndoas e avelãs) são as mais ricas em fibras, vitaminas e fitoquímicos antioxidantes. Para tirar o máximo partido das mesmas e evitar componentes nocivos, opte por fruta biológica, bem lavada.
No caso dos frutos gordos, antes de os ingerir, opte previamente por demolhá-los. Rejeite a água de demolhe e seque bem os frutos gordos.
Imagem retirada daqui.

How To Lock Computer and Laptop With Password In Hindi Urdu Tutorial

How To Lock Computer With Password In Hindi Urdu Tutorial
Change Password and Remove Password Your PC

How to frame a painting by François Boucher

A photo posted by Lauren (@mariegossip) on

Boucher's The Interrupted Sleep caught my eye while passing through the museum...

Read more »

How To Search Websites and Images Download in Hindi Urdu Tutorial

How To Search Websites and Images Download in Hindi Urdu Tutorial

Create Multiple Google Chrome Browser In Hindi Urdu Tutorial

Create Multiple Google Chrome Browser In Hindi Urdu Tutorial

How To Hide Desktop Icons In Hindi Urdu Tutorial

How To Hide Desktop Icons In Hindi Urdu Tutorial

How To Speed Up Your Computer in Hindi Urdu Tutorial

How To Speed Up Your Computer in Hindi Urdu Tutorial


Roll Turtle !

今天早上收到mail通知,《 Roll Turtle 滾滾龜 》得獎啦!(゚∀゚ )
分別是"年度最佳國際發展獎"以及"最佳應用獎 - 娛樂類",

一度被業界譽為「臺灣僅存最具指標性之 APP 競賽」,



《停車大聲公》 (年度最佳 APP、年度最佳新秀獎、最佳介面獎)
《Roll Turtle 滾滾龜》 (年度最佳國際發展獎、最佳應用獎 - 娛樂類)
《Whoscall》(最佳應用獎 - 公共服務類)
《友善新竹好藥局》(最佳應用獎 - 健康類)

除了Whoscall之外,還真的都是第一次聽到 (゚Д゚≡゚Д゚)?
到上次去Digital Taipei現場決選簡報的時候有10組團隊,
Roll Turtle有幸能成為最後獲得獎項的這5個app其中之一,
真的太開心啦 (・∀・)

畢竟Roll Turtle在下載量的部份其實還有很大的成長及努力空間,
也希望看看能不能透過獲獎的好兆頭,讓Roll Turtle能創造更好的下載成績。

因為這星期緊接著就要去中華電信的Hami app決賽了,
入圍決賽的作品除了Roll Turtle之外,


等獎金發放下來,也該買台新的給他慶祝一下了,這次就買會變形的吧 (o゚ω゚o)



Roy Boulting, 1968
Starring: Hywel Bennett, Hayley Mills, Billie Whitelaw

“No puppet master pulls the strings on high
Proportioning our parts, the tinsel and the paint
A twisted nerve, a ganglion gone awry,
Predestinates the sinner and the saint.”
—George Sylvester Viereck’s “Slaves”

A troubled young man, Martin, spies a pretty girl in a toy store while she’s making a purchase and he’s in the act of stealing a duck. Pretending to be mentally challenged, he gets away with a minor complaint against him and the girl, Susan, a librarian studying to become a teacher, takes pity on him. This leads to a dangerous infatuation with Susan, who comes to know him as “Georgie”; he goes so far as to get himself invited to live at the boarding house run by Susan’s mother. Martin’s brother Pete, who lives in an asylum, is actually handicapped and it is their family that seems to somehow be the root cause of Martin’s own disturbance; his anxious mother and domineering stepfather certainly don’t help matters. These tensions, combined with his fixation on Susan, lead him down a dark and violent path...

What the actual hell? Twisted Nerve has what is probably the most insane premise out of all the British young psycho killer films (with the possible exception of the far more brutal Night Must Fall, though that film begins far more conventionally); at minimum, Twisted Nerve definitely has the most tasteless premise. It certainly couldn’t be made today and even though this is likely to offend someone, somewhere, I can’t help but love the sheer cheek of it. Directed by the somewhat unknown Roy Boulting — of films like Design for Murder and There’s a Girl in My Soup, though he’s perhaps best known for producing his brother John’s absolutely amazing British noir Brighton Rock (1947)he does a solid job building suspense here.

But the film absolutely belongs to British television fixture Hywel Bennett, whose performance as Martin/Georgie is nearly able to overcome some of the film’s issues. In particular, his facial control is unforgettable, and much of his subdued, almost sedate performance lies in subtle changes of expression that indicate whether he’s still Martin or has switched into Georgie. Often this happens without a moment’s notice. And if it wasn’t enough that he’s pretending to have some sort of mental disorder out of boredom (and barely masked psychopathy), the film also pushes the limits of sexual content with some scenes of male nudity and implied masturbation. Martin seems to have body dysmorphic disorder, or at least some very serious sexual issues, akin to those of Peeping Tom.

An obvious precursor to this film, Peeping Tom’s screenwriter, the wonderful Leo Marks, also penned Twisted Nerve. Disturbingly, the title is taken from the above quoted poem by a fascinating but basically forgotten figure, George Viereck, a German-born writer. Viereck emigrated to the United States in the 1890s (around the same time as my own family, as a random side note of absolutely no interest to anyone but myself), where he developed a reputation as a poet — curiously one with homoerotic themes, which also appear in Twisted Nerve. As his writing career grew, thanks to some work in the fields of psychoanalysis and science, he met and developed relationships with everyone from Tesla to Hitler, and even Aleister Crowley. But Viereck was a staunch supporter of Hitler and eventually landed himself in prison in the US for his vigorous support of Nazism. He doesn’t have a whole lot to do with Twisted Nerve, but was too fascinating for me not to at least mention, and I can’t help but wonder if the well-read Marks — himself a veteran of the espionage and code-breaking fields during WWII — used Viereck as something of an inspiration for Martin.

It’s also a bit unfair to just rest the complete success of the film at the feet of either Marks or Bennett, as there’s a great supporting cast, which includes a number of established stage actors who also made appearances in genre films, such as Billie Whitelaw (The Omen) as Susan’s mother, Frank Finlay (The Deadly Bees) as Martin’s stepfather, and the delightful Barry Foster (Frenzy) as a lascivious tenant, whose side role is my favorite thing about the film. He's so wonderful that it's almost unfair to the other actors. It’s weird for me to see Hayley Mills in a horror movie — I’m familiar with her solely because of the Disney Channel’s incessant screening of The Parent Trap when I was a kid — but she’s very well used here in the sort of wide-eyed, well-meaning innocent role that pops up in a lot of these types of films. She begins to get wise to "Georgie," which at least elevates her a bit from the hapless victim type that Hammer couldn't get away from during this period.

Twisted Nerve comes recommended, though it’s probably not quite what you’d expect, unless you've seen a lot of these English psychopath films. There are a few murders — Martin uses his sudden lack of fixed identity and new residence to provide him with an alibi — though they are relatively bloodless or occur off-screen. The most famous thing about the film is actually the Bernard Herrmann score, which has one of the single most punishing songs in any horror film, though it should come as no surprise that Herrmann turns it into a compelling and oddly flexible theme that repeats throughout the film in several different ways; you’ll also probably recognize it from Kill Bill. Pick Twisted Nerve up on DVD. It’s got nothing on Straight on Till Morning, but really, what has?

Monsanto Bayer. It really is that ugly

They made explosives and lethally poisonous gases using shared technologies and sold them to both sides in both  World Wars. The same war chemicals were bought by the Allied Powers and the Axis Powers, from the same manufacturers, with money borrowed from the same federated reserve bank.
by Dr. Vandana Shiva, Global Research: 
GMO_vandanashiva650fiAward Winning Author and Scientist Dr. Vandana Shiva
India is steeped in synthesised controversy, created by Monsanto on the first GM crop supposedly-approved for commercialisation in India. Engaged in litigation on many fronts, Monsanto is trying to subvert our Patent Law, our Plant Variety and Farmers Rights Act, our Essential Commodities Act , our Anti Monopoly Act (Competition Act). It is behaving as if there is no Parliament, no Democracy, no Sovereign Laws in India to which it is subject. Or, it simply does not have any regard for them.
In another theatre, Monsanto and Bayer are merging. They were one as MOBAY (MonsantoBayer), part of the Poison Cartel of IG Farben. Controlling stakes of both Corporations lies with the same private equity firms.
he expertise of these companies are those of war. IG Farben – Hitler’s economic power and pre-war Germany’s highest foreign exchange earner – was also a foreign intelligence operation. Herman Shmitz was President of IG Farben, Shmitz’s nephew Max Ilgner was a Director of IG Farben, while Max’s brother Rudolph Ilgner handled the New York arm of the ‘VOWI‘ network as vice president of CHEMNYCO.
Paul Warburg – brother of Max Warburg (Board of Directors, Farben Aufsichsrat) – was one of the founding members of the Federal Reserve System in the United States. He was also a member of the Council on Foreign Relations. Max Warburg and Hermann Schmitz played a central role in the Farben empire. Other “guiding hands” of Farben Vorstand included Carl Bosch, Fritz ter Meer, Kurt Oppenheim and George von Schnitzler. Every one of them were adjudged ‘War Criminals’ after World War II, except Paul Warburg.
Monsanto and Bayer have a long history. They made explosives and lethally poisonous gases using shared technologies and sold them to both sides in both  World Wars. The same war chemicals were bought by the Allied Powers and the Axis Powers, from the same manufacturers, with money borrowed from the same federated reserve bank.
MOBAY (MonsantoBayer) supplied ingredients for Agent Orange in the Vietnam War. 20 million gallons of MOBAY defoliants and herbicides were sprayed over South Vietnam. Children are still being born with birth defects, adults have chronic illnesses and cancers, due to their exposure to MOBAY’s chemicals. Monsanto and Bayer’s cross-licensed Agent Orange Resistance has also been cross-developed for decades.
Wars were fought, lives were lost, countries carved into holy lands – with artificial boundaries that suit colonisation and resource grab – while Bayer and Monsanto sold chemicals as bombs and poisons and their brothers provided the loans to buy those bombs.
More recently, according to Monsanto’s website Bayer CropScience AG and Monsanto Co. have “entered into a series of long-term business and licensing agreements related to key enabling agricultural technologies”. This gives Monsanto and Bayer free access to each other’s herbicide and the paired herbicide resistance technology. Through cross licensing agreements like these, mergers and acquisitions, the biotech industry has become the IG Farben of today, with Monsanto in the cockpit.
The Global Chemical and GMO industry – Bayer, Dow Agro, DuPont Pioneer, Mahyco, Monsanto and Syngenta – have come together to form Federation of Seed Industry of India (FSII)  to try and become bigger bullies in this assault on India’s farmers, the environment , and democratically framed laws that protect the public and national interest.This is in addition to the lolly-group ABLE, the Association of Biotechnology Led Enterprises, which tried to challenge India’s Seed Price Control order issued under the Essential commodities Act, in the High Court of Karnataka. The case was dismissed.
The new Group is not “seed Industry”, they produce no seeds. And they try to stretch patents on chemicals to claim ownership on seed, even in countries where patents on seeds and plants are not allowed by law. This is the case in India, Argentina, Brazil, Mexico, and many other countries.
All the Monsanto cases in India are related to Monsanto un-scientifically, illegally and illegitimately claiming patents on seed, in contempt of India’s laws, and trying to collect royalties from the Indian seed industry and Indian farmers. The FSII is an “IG Farben 100 Year Family Reunion”, a federation is a coming together of independent and autonomous entities.
The Farben family chemical cartel was responsible for exterminating people in concentration camps . They embody a century of ecocide and genocide, carried out in the name of scientific experimentation and innovation. Today the poison cartel is wearing G-Engineering clothes, and citing the mantra of “innovation” ad nauseum. Hitlers concentration camps were an “innovation” in killing. 100 years later, the Farben Family are carrying out the same extermination, silently, globally, much more efficiently.
Monsanto’s “innovation” of collecting illegal royalties and pushing Indian farmers to suicide is also an innovation in killing without liability, indirectly. Just because there is a new way to kill does not make killing right, or a right. “Innovation” like every human activity, has limits – limits set by ethics, justice, democracy, the rights of people, the rights of nature.
I G Farben was tried at Nuremburg. We have national laws to protect people, their right to life and public health, and  the environment. India’s Biosafety laws and Patent, and Plant Variety Act are designed to regulate greedy owners of corporations – with a history of crimes against nature and humanity.
Industry is getting ready to push its next “gene” the  GM-Mustard (DMH-11). The GM mustard being promoted as a public sector “innovation” is based on barnase/barstar/ gene system to create male-sterile plants and a bar gene for Glufosinate Resistance.In 2002 Pro-Agro’s (Bayer) application for approval for commercial planting of GM Mustard based on the same system was rejected.
Although banned in India, Bayer finds ways to sell Glufosinate, to the tea gardens of Assam and the apple orchards of Himachal Pradesh, illegally. Sales agents show the Glufosinate sales under the ‘other’ category to avoid regulation. These chemicals are finding their way into the bodies of our children without government approval. Essentially all key patents related to the bar gene are held by Bayer Crop Science which acquired Aventis Cropscience, which itself was created out of the Genetic Engineering divisions of Schering, Rhone Poulenc and Hoechst. Then Bayer acquired Plant Genetics Systems, and entered into cooperation agreement with Evogene – which has patents on genome mapping.
Before any approval is granted to the Genetically Engineered Mustard, the issue of limits to patentability needs to be resolved on the basis of Indian law, patents on plants and seeds and methods of agriculture must not be allowed, because they are not allowed.
Pental, a retired professor and GM-Operative, will not commercialise GM Mustard seed. His Commanding Officers at Bayer/Monsanto/MOBAY will.
Given our experience with GMO cotton, the Ministry of Environment and Forests (MoEF) is considering the option of putting in place guidelines for socio-economic assessment to judge proposed GM varieties on the basis of factors such as economy, health, environment, society and culture.
At the core of socio economic assessment is the issue of monopolies and cartels and impact on small farmers. Even though patents on seeds are not allowed, for more that one and a half decade Monsanto has extracted illegal royalties from Indian farmers, trapping them in debt, and triggering an epidemic of farmers suicides. Monsanto’s war on India’s foot soldiers – farmers – is a war being waged by the Farben Family, on our Earth Family.